Seratonin and Mood: Evidence that Activity and Happiness are Connected

Serotonin, a hormone, is known to be an important chemical messenger that influences brain activity related to a wide range of functions, emotions and behaviors. These include circadian rhythms, moods, and thought. Disorders related to seratonin have been linked with impulsive violence, anxiety, and depression.

Higher levels of seratonin are associated with feelings of happiness and well-being. Too little seratonin is implicated in depression. But too much seratonin can be toxic and fatal. What is needed, it seems, is efficient regulation, which relates to having the right levels of seratonin and the right number of brain structures to use it appropriately. Current treatment approaches typically involve drugs that attempt to increase or decrease seratonin levels or improve its processing in order to achieve a satisfactory balance and the proper mood.

Because depression is a growing worldwide public health issue, new approaches to understanding this brain-mood-behavior phenomenon is in everyone's interest. That's why a recent editorial by the editor of the Journal of Psychiatry and Neuroscience is of interest here. The editorial, by Simon Young, suggests that new evidence supports the use of non-drug interventions in mood disorders related to seratonin.

Without going into the highly technical specifics of the science here, what Dr. Young suggests is that exposure to light, exercise, diet, and activities that lead to improved mood may all be examples of lifestyle- related strategies that can be used to address seratonin imbalances and prevent depression and its consequences. His article cited several promising studies that provide evidence for his "non drug intervention" proposal. I like this line of thinking, because it shows again that through lifestyle related interventions, people can influence their health and well-being. More emphasis on population-based approaches to preventing or treating health related disorders through lifestyle change must be a part of health care reform. Population based lifestyle intervention is smart, synergistic, humanistic, and economical.

Aligning Believing and Doing - Another Feature of Balanced Lifestyles?

A recent story on the NPR series called "This I Believe" featured an essay by a seven year old (Tarak McClain) of Austin, Texas. Tarak shortened his original list of 100 beliefs into a radio-ready list of 30, which he read on the air.

Aside from the remarkable fact that this very young man was thoughtful and wise enough to compose this list, (and poised enough to do an exemplary job of recording his interview), the notable feature of his story relates to his acting in ways that are consistent with his beliefs. Tarak has a commendable list of service projects to his credit already. This made me think about my recent posts on life balance, and one of the papers given at the life balance symposium I attended. This particular paper was about life balance as acting in accordance with personal values.

Values and beliefs are closely related. But few of us always stop to think (except on Sundays if we are church going Christians, or on other days if we practice other faiths) about how our actions align with what we profess to believe. For example, I believe in sustainability and conserving energy so that future generations will enjoy a high quality of life. But when I think about the actual things I am doing that are in alignment with this belief, I am embarrassed that the list is shorter than I would like. Perhaps this is why the phrase, "talk is cheap", was coined.

Tarak and I share some significant beliefs, and I suspect, that given the way 7 year old young men come to form their beliefs, that his parents have similar sentiments about community, peace, service to others, living in harmony and other values. But in the end, when it comes to making our communities and world better places, when actions and beliefs are aligned, we create the world we imagine. As Gandhi said "We must be the change we hope to see in the world."

I invite you to share your beliefs about living life well on this post, and to comment on the actions that reflect those beliefs.

Life Balance, What is it?

One of the aims of this blogsite is to promote dialogue about aspects of living well, focusing on how human activity, or how people use their time, contributes to their happiness, health and well-being. When it comes to lifestyles, daily routines can be regular, predictable and peaceful, or they can be volatile, unpredictable and stressful. Most of us experience lives that show characteristics of each extreme. Which is better? Should we be striving for steady state, and what would that be like? Is the journey through life best viewed as a highway metaphor where we try to maintain a course in the middle? How do we define that "middle ground"?

An earlier post in this series alluded to balance, pointing out that Michelle Obama, the incoming first lady, sees work-family balance as an important public health and family issue. Because lives out of balance are typically stressful, imbalance can be said to contribute to illness and chronic diseases, as pointed out in the post on resilience.

Most people intuitively understand that regular, predictable, and stress-avoidant routines are related to their well being, and thus they have a personal view of what life balance means, or what type of lifestyle works best for them.

Eighteen months ago, I had the privilege of participating in an international conference in Canada that brought together scientists and other experts from many disciplines for a discussion about life balance from theoretical and scientific perspectives. Although there were many interesting ideas expressed about how to define, study and otherwise understand life balance, another perspective examined during the meeting was philosophical. Is life balance a valid concept, or is it just another name for similar "positive states"? For example, is it the same idea as "well being" or "quality of life" with just another name?

My view is that all three concepts have features in common. However, life balance seems unique because it focuses specifically on how activity is organized within a life to help us achieve the outcomes we desire. I surmise that there is no one "life activity formula" that works for everyone, but that a successful formula must include certain characteristics or reflect identified principles.

What is your idea of a balanced life? What lifestyle characteristics do you think social scientists should consider in studying this concept? I look forward to reading your posts.

Sleep - Another type of healthful activity

It may not seem obvious, but in our daily round of activities, sleep must be counted among the most important. Recent reports have shown that teens in North America are sleep deprived, averaging less than seven hours per sleep per night when they require almost nine hours. Surely, cell phones, computers, online gaming, and television are part of the cause for this; but it would be too simple to say that teens don't sleep because they are absorbed by a more engaging activity.

In normal, healthy people, sleep is regulated or influenced by internal clocks, or circadian rhythms. The most germane of those rhythms that influence sleep is known as the rest-activity cycle. This cycle is influenced by hormones that are triggered by daylight, and a tiny gland in the skull known as the pineal gland has been implicated in explaining this. Humans evolved to be able to sleep during dark and be active during the day. Why? Because evolution works to maximize survival of species. Since humans see poorly in the dark, we are better off sleeping and being active during the daytime.

There is much to learn about sleep and how it serves to keep people healthy and mentally alert. We do know that it is vitally necessary to sleep. Extreme sleep deprivation can lead to death. We also know that normal sleep involves stages, and that the fourth stage, or Rapid Eye Movement (REM) stage of sleep, is thought to be the most important for its restorative properties. REM sleep is that stage of sleep during which we dream. If we don't achieve REM sleep, our sleep is of lesser quality. Normal humans go through several cycles involving all stages of sleep each night. People who sleep and say don't dream are simply not recalling their dreams.

Getting a good night's sleep (full of dreams) involves many factors. The most important factor for good sleep hygiene is having a rest-activity cycle that is entrained, or synchronized with what is happening in the social world. People need regular routines and activities to keep their internal clocks synchronized with the world. Jet lag after long distance air travel is a condition that places our internal clocks at odds with the social world around us when we fly to a new environment. Ordinarily, it can take as long as 30 days for the body to fully recover from jet lag.

Of course, shift workers are also at risk of insomnia caused by disentrainment, since shift workers must be active at night when their body tells them they should be sleeping. Of course, some adjustment does occur, as long as the shifts do not vary frequently. Some countries have laws that regulate shiftwork as a public health safeguard for such workers.

So, let's return to the issue of teens and sleep deprivation. It is likely that at least some of the sleep debt being accumulated by teens has less to do with the effects of more and more distracting late night activity than it does on the effects of such shiftwork on the internal clocks of the teens. It is likely that, like shift workers, teens' internal clocks have changed so that their rest-activity cycles have adjusted, so their body tells them they need to sleep until noon; while their parents and schools are telling them to get up at seven to begin classes or catch the bus! Thus it seems, their sleep deprivation is less about distracting activities, than it is about modified internal clocks.

Fyodor Who? on Activity and Happiness

Those avid readers among us will no doubt be able to quickly note that the title to this post refers to Russian author Fyodor Dostoyevski. Dostoyevski is among the most famous authors in history, and lived from 1821-1881. During his sixty year lifespan he wrote two fiction classics that are included on most great books lists, including The Brothers Karamozov and Crime and Punishment. In addition to being a great writer, Dostoyevski is sometimes credited as being one of the originators of the philosophy of existentialism.

So what does Dostoyevski have to do with this blogsite? Well, because doing is so important to our happiness and well being, those who love to read (and read and read) will certainly enjoy the works of Dostoyevski. But he appears in this blog not for that reason, but because he wrote an interesting passage about activity and happiness in a book of occasional writings. The excerpt is as follows:

"Our passion for some sort of activity reaches a point of feverish and uncontrollable impatience; we all long for some serious occupation, many of us are full of an ardent desire to do good, to be of some use, and we gradually begin to realize that happiness is not the same thing as being able to afford to sit about twiddling one's thumbs or just to do something for the sake of a change when the occasion arises, but consists of continual and tireless activity and the development of all faculties and capabilities in practice."

This observation by Dostoyevski is blogworthy here because it makes some interesting observations about activity and happiness. Reading along and between the lines, one might claim the following existential interpretation:

We serve our well-being best when we make choices about what we do that are consistent with our values and sense of self, and when those activities help us grow and become more competent. Indeed, it might be said that we create ourselves (our identities) through doing activities that are genuine, that allow us to express the joy of being and our uniqueness through creating or producing something that expresses some purpose or has meaning. Dan McAdams, whose studies of people's stories has been mentioned in other blogs and whose work is listed on this blogsite, coined the expression "selfing" to refer to this type of activity that serves self expression and beingness.

Think about what you do, and how many of those activities are done because of others, and how many were initiated with careful thought by you, the doer, to challenge and engage yourself, to help you realize your unique potential, and to truly make you feel "alive". Those kinds of activity choices are among the most important decisions we make.

What are you doing among your regular activities currently that makes you feel authentic? That may be a hard question to answer, but if you care to give it a try, please share it with others on this blogsite. And if you've a mind to, visit the wdydwyd? website to get a taste of how others express their authenticity.

As always, if you have a different perspective or a comment to add about anything written here, by all means, do it! Please share it here and now.

Thinking and Doing in Ways that Protect Health

This blogsite is about doing, so the key points in this post will not come as a surprise to readers. In a previous blog I promised to address the issue of resilience, or the body's ability to ward off the harmful effects of stress.

Many websites have lists of characteristics that are counterproductive to successful coping. Negative thinking, over-eating, obsessing, self blame, overworkiig and other detrimental behaviors and attitudes are widely known and may seem obvious as detriments to effective oping or health.

However, most web articles on this topic, including one from the highly acclaimed Mayo Clinic, overlook an important factor that is key to successful resilience. That factor is having engaging, meaningful, purposeful activities. If important preventive factors include a positive self concept and having opportunities for interacting with friends, it seems clear that doing things we enjoy with people we enjoy doing them with is likely to be a useful approach to promoting two critical dimensions of resilience: meaningful social relationships and a positive self concept. There is abundant literature to show that enjoyment in doing, which often comes from mastering challenge and doing something well, leads to better self esteem, improved positive feelings, and the release of hormones that are good for our immune system.

The theories of coping include strategies that have been called "active coping". Typically, these involve direct problem solving actions to address barriers that are frustrating, or dilemmas that are particularly stressful. What this post suggests is something different. What is suggested here is finding satisfying, engaging and meaningful activities that help us spend time enjoyably, have fun with others, and perhaps develop skills or a sense of completion that makes us feel good about ourselves.

I also recommend the strategies contained in this useful article by Tamar Chansky published in the Huffington Post. Dr. Chansky's recommendations offer more detailed variations on DLW's themes; namely, how we as individuals can create our own resilience through what we do (or avoid doing!).

Doing is not a universal elixir. But doing the right things helps us by keeping our immune systems stronger so that we can avoid the biological consequences of stress. Most importantly, if we build these practices into our daily lifestyles, and not just when we feel stressed, we will be making a habit of doing life well.

Stress is not good for you...not that you thought it was!!

If there is anything that can be said about life in the United States these days (or the world, for that matter), it's that there are lots of things going on that can cause worry or concern. It is a scientific fact that the most unhappy people in the population are those who are unemployed, so it should be seen as a societal concern that the unemployment rate is rising to levels not seen for decades. The new administration understands that the cost for not doing something will be far greater than the cost of an economic stimulus package, no matter how large. Why? Well, it's not just because people need to earn a living and buy things to get the economy back on track. It's also because economic downturns can affect public health by making the population more susceptible to illness.

But this blog post is not about politics or economic stimulus proposals. It's about stress and what it does to our bodies over time. We all generally perceive that being stressed out is not a good thing. But perhaps many of us feel that as long as we can get beyond the stressful periods and have some time for R&R (rest and recuperation), so to speak, we can shake off the consequences of stress and there will be no harm done.

The truth is, however, that over time, the effects of stress add up. It takes a toll on the body. And scientists now have a way of measuring that "toll" through objective means. These tests, which include blood pressure, cholesterol, and several other measures of "physiological" fitness, are collectively called "allostatic load". When the body responds to stressful circumstances, that process is called allostasis. Medical and psychological understanding of how stress shortens our lives and makes us susceptible to acute illnesses and longer term chronic diseases has now advanced rapidly. Scientists now have a better understanding of how the process works, and the area of "psychoneuroimmunology" or PNI, is where this knowledge is being gained.

The theory of how our worries activate hormones to tax our immune systems is too involved for this blog, but I recommend that interested readers take a look at a good book written in an interesting, understandable way called: Why Zebras Don't Get Ulcers, by Robert Sapolsky, PhD. The title of the book is a shorthand way of communicating the relationship between stress and health. Part of the reason we overtax our immune systems is because we worry about things that have happened to us or might happen to us. That worry signals our body to activate stress hormones that are good when they are needed, but harmful if they are around when they aren't needed. Dr. Sapolsky uses the example of the fire station that runs out of fuel and fresh men when it is constantly responding to false alarms, and compares that fire station to our immune systems, which are supposed to stamp out germs and other invaders to keep our bodies healthy. Immune systems get worn down by high and persistent levels of stress.

So...as my son once told me: "chillax". That was good advice. People who are able to chill and relax, are more resilient to the adverse consequences of stress. They experience less wear and tear on their bodies, and chances are, they will be more likely to live longer and healthier lives...and thus be able to "do life well." It turns out that resilience, or the ability to endure stress with fewer adverse consequences, is related to happiness. But that is a topic for a future blog post. Stay tuned!

(For readers interested in a readable but more complete and scientific account of allostasis and allostatic load on the web, go here.)